Micellar Pseudo-Models for Biological Membranes: Spectrophotometric Analysis of Micellar Binding of Antiviral (Oseltamivir Phosphate) and Anticoagulant (Enoxaparin Sodium)
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https://doi.org/10.62482/pmj.39Keywords:
Drug-membrane interaction, enoxaparin sodium, oseltamivir phosphate, spectrophotometry (UV-Vis), surfactant micellesAbstract
Introduction: The micellar environment formed by the aggregation of surfactants at a specific concentration, known as the critical micelle concentration (CMC), behaves like a simple biological system and is thus considered a pseudo-model of a biological system. Owing to these properties, which define them as mimetic systems, the microscopic environment created by surfactant micelles is similar to phospholipid membranes, allowing micelles to serve as models for biological membrane systems. Therefore, data on the binding of drugs to micelles is important as it can elucidate the drug's mechanism of action. Due to these interesting and unique physicochemical properties, surfactant micelles are widely used as a simple pseudo-model even for highly complex biomembranes. Therefore, this study aims to investigate the interactions of the antiviral drug Oseltamivir phosphate (OP) and the anticoagulant drug Enoxaparin sodium (ES) with different micellar systems.
Methods: The interactions of ES and OP with anionic, cationic, and nonionic surfactants were examined by the spectrophotometric method (UV-Vis), and their binding constants to micelles were calculated. Tween 20 (nonionic), sodium dodecyl sulfate (SDS) (anionic), and cetyltrimethylammonium bromide (CTAB) (cationic)-surfactants frequently used in pharmaceutical applications as models for mimetic systems-were selected for this study.
Results: The results of this study are expected to provide information about the behaviour of OP and ES in micellar systems that model biological membranes, as well as offer insight into the effectiveness of surfactants used in the improvement of drug formulations.
Conclusion: Given the importance of micellar systems in drug development, these results also offer practical insights for selecting the right pharmaceutical additives to create novel dissolving media for various applications.
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